LMOD3

Leiomodin-3 is a protein that in humans is encoded by the LMOD3 gene.^[5][6] Leiomodin-3 is especially present at the pointed end of muscle thin filaments.^[7]

LMOD3
Identifiers
Aliases	LMOD3, NEM10, leiomodin 3
External IDs	OMIM: 616112; MGI: 2444169; HomoloGene: 28097; GeneCards: LMOD3; OMA:LMOD3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.1 Start 69,106,065 bp[1] End 69,123,032 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D3 Start 97,215,495 bp[2] End 97,229,720 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii vastus lateralis muscle skeletal muscle tissue Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii muscle of thigh deltoid muscle gastrocnemius muscle myocardium of left ventricle tibialis anterior muscle Top expressed in soleus muscle intercostal muscle tibialis anterior muscle sternocleidomastoid muscle medial head of gastrocnemius muscle temporal muscle quadriceps femoris muscle ankle digastric muscle vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin monomer binding tropomyosin binding Cellular component cytoskeleton A band cytoplasm striated muscle thin filament M band myofibril Biological process pointed-end actin filament capping skeletal muscle fiber development muscle contraction actin filament organization myofibril assembly striated muscle contraction skeletal muscle thin filament assembly actin nucleation positive regulation of skeletal muscle fiber development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56203 320502 Ensembl ENSG00000163380 ENSMUSG00000044086 UniProt Q0VAK6 E9QA62 RefSeq (mRNA) NM_198271 NM_001304418 NM_001081157 RefSeq (protein) NP_001291347 NP_938012 NP_001074626 Location (UCSC) Chr 3: 69.11 – 69.12 Mb Chr 6: 97.22 – 97.23 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

Dysfunction is associated with thin filament disorganisation and nemaline myopathy.^[8]