LNX1

E3 ubiquitin-protein ligase LNX is an enzyme that in humans is encoded by the LNX1 gene.^[5][6][7]

LNX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B76
Identifiers
Aliases	LNX1, LNX, MPDZ, PDZRN2, ligand of numb-protein X 1
External IDs	OMIM: 609732; MGI: 1278335; HomoloGene: 7819; GeneCards: LNX1; OMA:LNX1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q12 Start 53,459,301 bp[1] End 53,701,405 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.3 Start 74,753,108 bp[2] End 74,863,573 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus parotid gland Brodmann area 23 endothelial cell Brodmann area 46 oral cavity amniotic fluid skin of arm superior frontal gyrus jejunal mucosa Top expressed in motor neuron facial motor nucleus substantia nigra vestibular membrane of cochlear duct Paneth cell right ventricle epithelium of stomach lacrimal gland transitional epithelium of urinary bladder anterior horn of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function PDZ domain binding protein binding metal ion binding ubiquitin-protein transferase activity transferase activity zinc ion binding Cellular component cytoplasm Biological process protein homooligomerization protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84708 16924 Ensembl ENSG00000072201 ENSMUSG00000029228 UniProt Q8TBB1 O70263 RefSeq (mRNA) NM_001126328 NM_032622 NM_001159577 NM_001159578 NM_001159579 NM_001159580 NM_010727 NM_001359074 RefSeq (protein) NP_001119800 NP_116011 NP_001153049 NP_001153050 NP_001153051 NP_001153052 NP_034857 NP_001346003 Location (UCSC) Chr 4: 53.46 – 53.7 Mb Chr 5: 74.75 – 74.86 Mb PubMed search [3] [4]
Wikidata
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Interactions

LNX1 has been shown to interact with NAGK,^[8] NUMB^[6] and PAFAH1B3.^[8]