LPAR4

Lysophosphatidic acid receptor 4 also known as LPA₄ is a protein that in humans is encoded by the LPAR4 gene.^[5][6][7] LPA₄ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[8]

LPAR4
Identifiers
Aliases	LPAR4, GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9, lysophosphatidic acid receptor 4
External IDs	OMIM: 300086; MGI: 1925384; HomoloGene: 3871; GeneCards: LPAR4; OMA:LPAR4 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.1 Start 78,747,709 bp[1] End 78,758,714 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 105,964,231 bp[2] End 105,977,506 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve buccal mucosa cell tibia testicle gonad ventricular zone cartilage tissue ganglionic eminence muscle of thigh Achilles tendon Top expressed in dermis pituitary stalk efferent ductule human fetus primitive streak trigeminal ganglion tongue Gonadal ridge mandibular prominence left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lysophosphatidic acid binding signal transducer activity lipid binding G protein-coupled receptor activity lysophosphatidic acid receptor activity Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane nuclear body intracellular membrane-bounded organelle Biological process signal transduction positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2846 78134 Ensembl ENSG00000147145 ENSMUSG00000049929 UniProt Q99677 Q8BLG2 RefSeq (mRNA) NM_001278000 NM_005296 NM_175271 RefSeq (protein) NP_001264929 NP_005287 NP_780480 Location (UCSC) Chr X: 78.75 – 78.76 Mb Chr X: 105.96 – 105.98 Mb PubMed search [3] [4]
Wikidata
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See also

• Lysophospholipid receptor
• P2Y receptor