LPP (gene)

Lipoma-preferred partner is a protein that in humans is encoded by the LPP gene.^[5][6]

LPP
Identifiers
Aliases	LPP, LIM domain containing preferred translocation partner in lipoma
External IDs	OMIM: 600700; MGI: 2441849; HomoloGene: 4075; GeneCards: LPP; OMA:LPP - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.3-q28 Start 188,153,284 bp[1] End 188,890,671 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B1 Start 24,393,507 bp[2] End 24,992,578 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein urethra vena cava nipple pylorus tail of epididymis cardia seminal vesicula epithelium of colon superficial temporal artery Top expressed in ascending aorta aortic valve Paneth cell umbilical cord tunica media of zone of aorta endothelial cell of lymphatic vessel conjunctival fornix urinary bladder cervix Ileal epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding Cellular component cell junction plasma membrane membrane nucleus focal adhesion cytoplasm cytosol stress fiber Biological process cell adhesion biological process cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4026 210126 Ensembl ENSG00000145012 ENSMUSG00000033306 UniProt Q93052 Q8BFW7 RefSeq (mRNA) NM_001167671 NM_001167672 NM_005578 NM_001375455 NM_001375456 NM_001375457 NM_001375458 NM_001375459 NM_001375460 NM_001375461 NM_001375462 NM_001375463 NM_001375464 NM_001375465 NM_001145952 NM_001145954 NM_178665 RefSeq (protein) NP_001161143 NP_001161144 NP_005569 NP_001362384 NP_001362385 NP_001362386 NP_001362387 NP_001362388 NP_001362389 NP_001362390 NP_001362391 NP_001362392 NP_001362393 NP_001362394 NP_001139424 NP_001139426 NP_848780 Location (UCSC) Chr 3: 188.15 – 188.89 Mb Chr 16: 24.39 – 24.99 Mb PubMed search [3] [4]
Wikidata
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Function

Lipoma-preferred partner is a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of fusion proteins that may promote tumor growth.^[6]