LPXN

Leupaxin is a protein that in humans is encoded by the LPXN gene.^[5][6]

LPXN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X3H, 4XEF, 4XEK, 4XEV
Identifiers
Aliases	LPXN, LDPL, leupaxin
External IDs	OMIM: 605390; MGI: 2147677; HomoloGene: 3536; GeneCards: LPXN; OMA:LPXN - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 58,526,871 bp[1] End 58,578,220 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 12,773,557 bp[2] End 12,811,171 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus granulocyte mononuclear cell monocyte appendix lymph node blood spleen mucosa of ileum epithelium of nasopharynx Top expressed in mesenteric lymph nodes spermatocyte stroma of bone marrow spleen thymus seminiferous tubule blood spermatid medulla of thymus subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transcription coregulator activity metal ion binding Cellular component cytoplasm perinuclear region of cytoplasm podosome cell junction plasma membrane cell projection nucleus focal adhesion membrane cytosol nuclear speck Biological process negative regulation of B cell receptor signaling pathway negative regulation of cell adhesion cell adhesion regulation of cell adhesion mediated by integrin regulation of transcription, DNA-templated transcription, DNA-templated signal transduction protein-containing complex assembly regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9404 107321 Ensembl ENSG00000110031 ENSMUSG00000024696 UniProt O60711 Q99N69 RefSeq (mRNA) NM_001143995 NM_001307951 NM_004811 NM_134152 NM_001361971 RefSeq (protein) NP_001137467 NP_001294880 NP_004802 NP_598913 NP_001348900 Location (UCSC) Chr 11: 58.53 – 58.58 Mb Chr 19: 12.77 – 12.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity.^[6]