LRCH4

Leucine-rich repeat and calponin homology domain-containing protein 4 is a protein that in humans is encoded by the LRCH4 gene.^[5][6]

LRCH4
Identifiers
Aliases	LRCH4, LRN, LRRN1, LRRN4, PP14183, leucine-rich repeats and calponin homology (CH) domain containing 4, leucine rich repeats and calponin homology domain containing 4
External IDs	MGI: 1917193; HomoloGene: 20532; GeneCards: LRCH4; OMA:LRCH4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,574,011 bp[1] End 100,586,129 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 137,627,383 bp[2] End 137,639,361 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right testis left testis blood spleen pituitary gland monocyte right ovary left ovary anterior pituitary Top expressed in granulocyte secondary oocyte zygote primary oocyte thymus spleen testicle bone marrow genital tubercle tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component PML body cytoplasm basolateral plasma membrane Biological process nervous system development signal transduction maintenance of epithelial cell apical/basal polarity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4034 231798 Ensembl ENSG00000077454 ENSMUSG00000093445 UniProt O75427 Q921G6 RefSeq (mRNA) NM_002319 NM_001289934 NM_001168652 NM_146164 RefSeq (protein) NP_001276863 NP_002310 NP_001162123 NP_666276 Location (UCSC) Chr 7: 100.57 – 100.59 Mb Chr 5: 137.63 – 137.64 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor.^[6]