LRRC4

Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.^[5][6]

LRRC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DL9, 3ZYI
Identifiers
Aliases	LRRC4, NGL-2, NAG14, leucine rich repeat containing 4
External IDs	OMIM: 610486; MGI: 2182081; HomoloGene: 36403; GeneCards: LRRC4; OMA:LRRC4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.1 Start 128,027,071 bp[1] End 128,032,107 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.3 Start 28,661,830 bp[2] End 28,831,746 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone prefrontal cortex right frontal lobe bronchial epithelial cell dorsolateral prefrontal cortex Brodmann area 9 right hemisphere of cerebellum cingulate gyrus anterior cingulate cortex cerebellar vermis Top expressed in interventricular septum dentate gyrus of hippocampal formation granule cell visual cortex primary visual cortex piriform cortex cingulate gyrus superior frontal gyrus lobe of cerebellum hippocampus proper primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase inhibitor activity protein binding Cellular component cytoplasm integral component of membrane neuron spine cell junction postsynaptic membrane dendritic spine plasma membrane synapse excitatory synapse membrane Schaffer collateral - CA1 synapse glutamatergic synapse integral component of postsynaptic density membrane Biological process synapse organization postsynaptic density protein 95 clustering regulation of synapse organization negative regulation of protein kinase activity cytokine-mediated signaling pathway negative regulation of receptor signaling pathway via JAK-STAT modulation of chemical synaptic transmission synaptic membrane adhesion excitatory synapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64101 192198 Ensembl ENSG00000128594 ENSMUSG00000049939 UniProt Q9HBW1 Q99PH1 RefSeq (mRNA) NM_022143 NM_138682 RefSeq (protein) NP_071426 NP_619623 Location (UCSC) Chr 7: 128.03 – 128.03 Mb Chr 6: 28.66 – 28.83 Mb PubMed search [3] [4]
Wikidata
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This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.^[6] Also it has been identified as a possible pathogenic gene involved in the neurogenic inflammation in rosacea.^[7]