LRRTM1

LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons.^[5][6] As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).^[7][8]

LRRTM1
Identifiers
Aliases	LRRTM1, entrez:347730, leucine rich repeat transmembrane neuronal 1
External IDs	OMIM: 610867; MGI: 2389173; HomoloGene: 41763; GeneCards: LRRTM1; OMA:LRRTM1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p12 Start 80,288,351 bp[1] End 80,304,752 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 77,219,672 bp[2] End 77,234,774 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus prefrontal cortex nucleus accumbens caudate nucleus middle temporal gyrus putamen Brodmann area 9 cingulate gyrus anterior cingulate cortex right frontal lobe Top expressed in lateral geniculate nucleus medial dorsal nucleus medial geniculate nucleus hippocampus proper barrel cortex subiculum Temporal Lobe dentate gyrus piriform cortex nucleus accumbens More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase inhibitor activity molecular function Cellular component integral component of membrane postsynaptic membrane membrane growth cone plasma membrane synapse excitatory synapse cell surface axon cell junction endoplasmic reticulum extracellular space extracellular matrix glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of postsynaptic specialization membrane Biological process locomotory behavior negative regulation of protein kinase activity cytokine-mediated signaling pathway negative regulation of receptor internalization synapse organization exploration behavior protein localization to synapse long-term potentiation negative regulation of receptor signaling pathway via JAK-STAT positive regulation of synapse assembly biological process regulation of postsynaptic density assembly regulation of presynapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 347730 74342 Ensembl ENSG00000162951 ENSMUSG00000060780 UniProt Q86UE6 Q8K377 RefSeq (mRNA) NM_178839 NM_028880 NM_001362109 RefSeq (protein) NP_849161 NP_083156 NP_001349038 Location (UCSC) Chr 2: 80.29 – 80.3 Mb Chr 6: 77.22 – 77.23 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

LRRTM1 is the first gene linked to increased odds of being left-handed, when inherited from the father's side.^[9] Possessing one particular variant of the LRRTM1 gene slightly raises the risk of psychotic mental illnesses such as schizophrenia, again only if inherited from the father's side.^[9] As well, LRRTM1 has been associated with measures of schizotypy in non-clinical populations,^[10] indicating that the gene may have shared effects on neurodevelopment in both healthy and unhealthy individuals and individuals with schizophrenia.

LRRTM1 is also critically involved in synapse formation within the dorsal lateral geniculate nucleus (dLGN) of mice. LRRTM1 aids in the assembly of complex retinogeniculate synapses in mice, which are believed to help process complex visual signals. Lack of this gene shows decreased performance in complex visual tasks.^[11]

See also

• Handedness