LSM4

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.^[5][6][7]

LSM4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	LSM4, GRP, YER112W, LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	OMIM: 607284; MGI: 1354692; HomoloGene: 134555; GeneCards: LSM4; OMA:LSM4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,306,236 bp[1] End 18,323,112 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 71,125,898 bp[2] End 71,131,402 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right testis left testis ventricular zone right adrenal gland right adrenal cortex left adrenal cortex embryo ganglionic eminence apex of heart Top expressed in yolk sac thymus bone marrow lens epiblast ventricular zone proximal tubule embryo ileum ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding U6 snRNA binding RNA binding PH domain binding Cellular component spliceosomal tri-snRNP complex U6 snRNP P-body nucleoplasm neuron projection spliceosomal complex nucleus cytosol membrane protein-containing complex U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome Lsm2-8 complex Biological process RNA processing mRNA processing spliceosomal snRNP assembly spliceosomal complex assembly P-body assembly exonucleolytic catabolism of deadenylated mRNA RNA splicing mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25804 50783 Ensembl ENSG00000130520 ENSMUSG00000031848 UniProt Q9Y4Z0 Q9QXA5 RefSeq (mRNA) NM_012321 NM_001252129 NM_015816 NM_001359042 RefSeq (protein) NP_001239058 NP_036453 NP_056631 NP_001345971 Location (UCSC) Chr 19: 18.31 – 18.32 Mb Chr 8: 71.13 – 71.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[7]