LSM5

U6 snRNA-associated Sm-like protein LSm5 is a protein that in humans is encoded by the LSM5 gene.^[5][6][7]

LSM5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	LSM5, YER146W, LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	OMIM: 607285; MGI: 1913623; HomoloGene: 40833; GeneCards: LSM5; OMA:LSM5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.3 Start 32,485,338 bp[1] End 32,495,283 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B3 Start 56,678,048 bp[2] End 56,681,695 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence human penis rectum superior surface of tongue mucosa of transverse colon body of pancreas jejunum pylorus bone marrow Top expressed in embryo embryo epiblast ventricular zone morula primary oocyte yolk sac thymus neural tube blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component U6 snRNP cytosol Lsm1-7-Pat1 complex U4/U6 x U5 tri-snRNP complex spliceosomal complex nucleus nucleoplasm U2-type precatalytic spliceosome Lsm2-8 complex Biological process nuclear-transcribed mRNA catabolic process mRNA splicing, via spliceosome mRNA processing exonucleolytic catabolism of deadenylated mRNA RNA splicing response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23658 66373 Ensembl ENSG00000106355 ENSMUSG00000091625 UniProt Q9Y4Y9 P62322 RefSeq (mRNA) NM_001130710 NM_001139499 NM_012322 NM_025520 RefSeq (protein) NP_001124182 NP_001132971 NP_036454 NP_079796 Location (UCSC) Chr 7: 32.49 – 32.5 Mb Chr 6: 56.68 – 56.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[7]