LUC7L3

LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.^[5]

LUC7L3
Identifiers
Aliases	LUC7L3, CRA, CREAP-1, CROP, LUC7A, OA48-18, hLuc7A, LUC7 like 3 pre-mRNA splicing factor
External IDs	OMIM: 609434; MGI: 1914934; HomoloGene: 75056; GeneCards: LUC7L3; OMA:LUC7L3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 50,719,565 bp[1] End 50,756,219 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 94,178,716 bp[2] End 94,212,814 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pylorus sural nerve right hemisphere of cerebellum endothelial cell cardia tibia cerebellar vermis left ovary seminal vesicula corpus callosum Top expressed in medullary collecting duct genital tubercle Rostral migratory stream Paneth cell renal corpuscle tail of embryo ciliary body retinal pigment epithelium neural layer of retina fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding mRNA binding RNA binding Cellular component U1 snRNP U2-type prespliceosome nucleus nucleoplasm nuclear speck Biological process mRNA processing mRNA splice site selection RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51747 67684 Ensembl ENSG00000108848 ENSMUSG00000020863 UniProt O95232 Q5SUF2 RefSeq (mRNA) NM_006107 NM_016424 NM_001330330 NM_026313 NM_001361573 NM_001361574 NM_001361575 RefSeq (protein) NP_001317259 NP_006098 NP_057508 NP_080589 NP_001348502 NP_001348503 NP_001348504 Location (UCSC) Chr 17: 50.72 – 50.76 Mb Chr 11: 94.18 – 94.21 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a cisplatin resistance-associated overexpressed protein (CROP). The N-terminal half of the CROP contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[5]