LYAR

Cell growth-regulating nucleolar protein is a protein that in humans is encoded by the LYAR gene (Ly-1 antibody reactive clone).^[5]

LYAR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WJV
Identifiers
Aliases	LYAR, ZC2HC2, ZLy1 antibody reactive
External IDs	OMIM: 617684; MGI: 107470; HomoloGene: 41200; GeneCards: LYAR; OMA:LYAR - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 4,267,701 bp[1] End 4,290,154 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B3|5 20.29 cM Start 38,377,814 bp[2] End 38,391,650 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte left testis sperm right testis granulocyte tendon of biceps brachii monocyte pericardium lymph node myocardium of left ventricle Top expressed in otic placode spermatid otic vesicle seminiferous tubule spermatocyte saccule tail of embryo epiblast neural layer of retina embryo More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding protein binding RNA binding DNA binding Cellular component nucleus nucleolus photoreceptor outer segment cytoplasm cell projection Biological process negative regulation of transcription by RNA polymerase II rRNA processing erythrocyte development positive regulation of phagocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55646 17089 Ensembl ENSG00000145220 ENSMUSG00000067367 UniProt Q9NX58 Q08288 RefSeq (mRNA) NM_001145725 NM_017816 NM_025281 RefSeq (protein) NP_001139197 NP_060286 NP_079557 Location (UCSC) Chr 4: 4.27 – 4.29 Mb Chr 5: 38.38 – 38.39 Mb PubMed search [3] [4]
Wikidata
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LYAR contains a zinc finger motif and three copies of nuclear localization signals. LYAR is mainly localized to the nucleoli. LYAR is present at high levels in early embryos and preferentially in the liver fetal thymus.^[6]