LYL1

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.^[5][6]

LYL1
Identifiers
Aliases	LYL1, bHLHa18, lymphoblastic leukemia associated hematopoiesis regulator 1, basic helix-loop-helix family member, LYL1 basic helix-loop-helix family member
External IDs	OMIM: 151440; MGI: 96891; HomoloGene: 4078; GeneCards: LYL1; OMA:LYL1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 13,099,033 bp[1] End 13,103,161 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C3|8 41.02 cM Start 85,428,078 bp[2] End 85,431,569 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte monocyte trabecular bone bone marrow spleen bone marrow cells vena cava superficial temporal artery lymph node Top expressed in granulocyte spleen bone marrow tibiofemoral joint stroma of bone marrow fetal liver hematopoietic progenitor cell blood mesenteric lymph nodes interventricular septum endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process positive regulation of transcription, DNA-templated B cell differentiation definitive hemopoiesis regulation of transcription, DNA-templated transcription, DNA-templated blood vessel maturation regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4066 17095 Ensembl ENSG00000104903 ENSMUSG00000034041 UniProt P12980 P27792 RefSeq (mRNA) NM_005583 NM_008535 RefSeq (protein) NP_005574 NP_032561 Location (UCSC) Chr 19: 13.1 – 13.1 Mb Chr 8: 85.43 – 85.43 Mb PubMed search [3] [4]
Wikidata
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Interactions

LYL1 has been shown to interact with TCF3^[7] and NFKB1.^[8]