LYPLA1

Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene.^[5][6]

LYPLA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FJ2
Identifiers
Aliases	LYPLA1, APT-1, APT1, LPL-I, LPL1, hAPT1, lysophospholipase I, lysophospholipase 1
External IDs	OMIM: 605599; MGI: 1344588; HomoloGene: 100781; GeneCards: LYPLA1; OMA:LYPLA1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q11.23 Start 54,046,367 bp[1] End 54,102,017 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A1 Start 4,878,011 bp[2] End 4,918,633 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in human penis oral cavity gonad vulva right ventricle skin of thigh mucosa of sigmoid colon epithelium of nasopharynx superior surface of tongue biceps brachii Top expressed in right kidney gallbladder superior surface of tongue intercostal muscle jejunum epithelium of small intestine cardiac muscle tissue of left ventricle gastrula extensor digitorum longus muscle plantaris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lysophospholipase activity hydrolase activity lipase activity palmitoyl-(protein) hydrolase activity carboxylic ester hydrolase activity protein binding Cellular component cytoplasm cytosol extracellular exosome mitochondrion Biological process protein depalmitoylation regulation of nitric-oxide synthase activity negative regulation of Golgi to plasma membrane protein transport fatty acid metabolic process lipid metabolism metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10434 18777 Ensembl ENSG00000120992 ENSMUSG00000025903 UniProt O75608 Q6IAQ1 P97823 RefSeq (mRNA) NM_001279356 NM_001279357 NM_001279358 NM_001279359 NM_001279360 NM_006330 NM_008866 NM_001355712 RefSeq (protein) NP_001266285 NP_001266286 NP_001266287 NP_001266288 NP_001266289 NP_006321 NP_006321.1 NP_032892 NP_001342641 Location (UCSC) Chr 8: 54.05 – 54.1 Mb Chr 1: 4.88 – 4.92 Mb PubMed search [3] [4]
Wikidata
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Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.^[6]