LZTS1

Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene.^[5][6][7]

LZTS1
Identifiers
Aliases	LZTS1, F37, FEZ1, leucine zipper, putative tumor suppressor 1, leucine zipper tumor suppressor 1
External IDs	OMIM: 606551; MGI: 2684762; HomoloGene: 10873; GeneCards: LZTS1; OMA:LZTS1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 20,246,165 bp[1] End 20,303,963 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 69,585,321 bp[2] End 69,636,877 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence nucleus accumbens Brodmann area 23 primary visual cortex right frontal lobe caudate nucleus amygdala prefrontal cortex putamen dorsolateral prefrontal cortex Top expressed in olfactory tubercle piriform cortex dorsal striatum Rostral migratory stream Region I of hippocampus proper lumbar spinal ganglion lateral septal nucleus superior frontal gyrus nucleus accumbens primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity protein binding microtubule binding Cellular component cytoplasm postsynaptic membrane cell projection membrane postsynaptic density plasma membrane dendritic spine synapse cell junction apical plasma membrane neuron projection dendritic shaft cell body Biological process negative regulation of macroautophagy transcription, DNA-templated cell cycle regulation of transcription, DNA-templated mitotic cell cycle phase transition regulation of synaptic plasticity regulation of dendrite morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11178 211134 Ensembl ENSG00000061337 ENSMUSG00000036306 UniProt Q9Y250 P60853 RefSeq (mRNA) NM_021020 NM_001362884 NM_199364 NM_001370971 RefSeq (protein) NP_066300 NP_001349813 NP_955396 NP_001357900 Location (UCSC) Chr 8: 20.25 – 20.3 Mb Chr 8: 69.59 – 69.64 Mb PubMed search [3] [4]
Wikidata
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In melanocytic cells LZTS1 gene expression may be regulated by MITF.^[8]

Interactions

LZTS1 has been shown to interact with EEF1G.^[9]