Lactate dehydrogenase A

Lactate dehydrogenase A (LDHA) is an enzyme which in humans is encoded by the LDHA gene.^[5] It is a monomer of lactate dehydrogenase, which exists as a tetramer. The other main subunit is lactate dehydrogenase B (LDHB).

LDHA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I10, 4AJP, 4JNK, 4L4R, 4L4S, 4M49, 4OJN, 4OKN, 4QO7, 4QO8, 4QSM, 4QT0, 4R68, 4R69, 4RLS, 4ZVV
Identifiers
Aliases	LDHA, GSD11, HEL-S-133P, LDH1, LDHM, PIG19, lactate dehydrogenase A
External IDs	OMIM: 150000; MGI: 96759; HomoloGene: 56495; GeneCards: LDHA; OMA:LDHA - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.1 Start 18,394,560 bp[1] End 18,408,425 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 30.6 cM Start 46,490,899 bp[2] End 46,505,051 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone skin of leg tibial arteries skin of abdomen muscle of leg Achilles tendon epithelium of colon ascending aorta right adrenal gland gastrocnemius muscle Top expressed in otic placode somite primitive streak otic vesicle epiblast triceps brachii muscle vastus lateralis muscle sternocleidomastoid muscle medial head of gastrocnemius muscle saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor NAD binding lactate dehydrogenase activity kinase binding protein binding catalytic activity identical protein binding oxidoreductase activity L-lactate dehydrogenase activity cadherin binding Cellular component cytoplasm membrane extracellular exosome nucleus cytosol Biological process post-embryonic animal organ development lactate metabolic process response to hypoxia glycolytic process response to organic cyclic compound substantia nigra development response to nutrient carboxylic acid metabolic process response to glucose NAD metabolic process response to estrogen pyruvate metabolic process positive regulation of apoptotic process response to cAMP response to hydrogen peroxide carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3939 16828 Ensembl ENSG00000134333 ENSG00000288299 ENSMUSG00000063229 UniProt P00338 P06151 RefSeq (mRNA) NM_001135239 NM_001165414 NM_001165415 NM_001165416 NM_005566 NM_001136069 NM_010699 RefSeq (protein) NP_001128711 NP_001158886 NP_001158887 NP_001158888 NP_005557 NP_001129541 NP_034829 Location (UCSC) Chr 11: 18.39 – 18.41 Mb Chr 7: 46.49 – 46.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Lactate dehydrogenase A catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD⁺. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumors, and belongs to the lactate dehydrogenase family. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria.^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

LDHA Inhibitors

The following compounds have been demonstrated to inhibit the LDHA enzyme:

• Oxamate^[7]
• Epigallocatechin gallate^[8]
• Quinoline 3-sulfonamide^[9]
• CHK-336^[10]