Lactate dehydrogenase b

Lactate dehydrogenase B is a protein that in humans is encoded by the LDHB gene. ^[5]

LDHB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I0Z, 1T2F
Identifiers
Aliases	LDHB, HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5, lactate dehydrogenase B
External IDs	OMIM: 150100; MGI: 96763; HomoloGene: 55647; GeneCards: LDHB; OMA:LDHB - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.1 Start 21,635,342 bp[1] End 21,757,857 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G2|6 74.17 cM Start 142,435,975 bp[2] End 142,453,683 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla right ventricle external globus pallidus endothelial cell lateral nuclear group of thalamus myocardium of left ventricle pars compacta pars reticulata kidney tubule middle temporal gyrus Top expressed in primary oocyte secondary oocyte zygote right kidney right ventricle primary visual cortex superior frontal gyrus vestibular membrane of cochlear duct anterior horn of spinal cord proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity lactate dehydrogenase activity protein binding kinase binding NAD binding catalytic activity L-lactate dehydrogenase activity identical protein binding Cellular component extracellular exosome membrane raft membrane myelin sheath mitochondrion cytoplasm cytosol Biological process NAD metabolic process lactate metabolic process carboxylic acid metabolic process pyruvate metabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3945 16832 Ensembl ENSG00000111716 ENSMUSG00000030246 UniProt P07195 P16125 RefSeq (mRNA) NM_001174097 NM_002300 NM_001315537 NM_008492 NM_001302765 NM_001316322 RefSeq (protein) NP_001167568 NP_001302466 NP_002291 NP_001289694 NP_001303251 NP_032518 Location (UCSC) Chr 12: 21.64 – 21.76 Mb Chr 6: 142.44 – 142.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13.