Laminin subunit alpha-2

Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene.^[5][6][7]

LAMA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YEP, 4YEQ
Identifiers
Aliases	LAMA2, LAMM, Laminin, alpha 2, laminin subunit alpha 2, MDC1A
External IDs	OMIM: 156225; MGI: 99912; HomoloGene: 37306; GeneCards: LAMA2; OMA:LAMA2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.33 Start 128,883,138 bp[1] End 129,516,566 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 A4|10 14.23 cM Start 26,856,032 bp[2] End 27,495,754 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa Achilles tendon right ovary left ovary right lung atrium right auricle of heart myocardium of left ventricle cardiac muscle tissue of right atrium pericardium Top expressed in sciatic nerve epithelium of lens efferent ductule utricle vestibular sensory epithelium ascending aorta vas deferens aortic valve right ventricle plantaris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity signaling receptor binding extracellular matrix structural constituent Cellular component extracellular region dendritic spine sarcolemma basement membrane extracellular matrix neuromuscular junction synaptic cleft collagen-containing extracellular matrix Biological process muscle organ development regulation of cell migration positive regulation of synaptic transmission, cholinergic regulation of embryonic development regulation of cell adhesion axon guidance cell adhesion Schwann cell differentiation extracellular matrix organization animal organ morphogenesis tissue development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3908 16773 Ensembl ENSG00000196569 ENSMUSG00000019899 UniProt P24043 Q60675 RefSeq (mRNA) NM_000426 NM_001079823 NM_008481 RefSeq (protein) NP_000417 NP_001073291 NP_032507 Location (UCSC) Chr 6: 128.88 – 129.52 Mb Chr 10: 26.86 – 27.5 Mb PubMed search [3] [4]
Wikidata
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Function

Laminin, an extracellular matrix protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.^[7]