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Lecithin retinol acyltransferase
Mammalian protein found in Homo sapiens From Wikipedia, the free encyclopedia
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Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene.[5][6]
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Function
Lecithin retinol acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver.
Clinical significance
Mutations in this gene have been associated with early-onset severe retinal dystrophy.[6]
LRAT was overexpressed in colorectal cancer cells compared to normal colonic epithelium. Strong LRAT expression was associated with a poor prognosis in patients with colorectal cancer.[7]
See also
References
Further reading
External links
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