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Lecithin retinol acyltransferase

Mammalian protein found in Homo sapiens From Wikipedia, the free encyclopedia

Lecithin retinol acyltransferase
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Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene.[5][6]

Quick facts LRAT, Available structures ...
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Function

Lecithin retinol acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver.

Clinical significance

Mutations in this gene have been associated with early-onset severe retinal dystrophy.[6]

LRAT was overexpressed in colorectal cancer cells compared to normal colonic epithelium. Strong LRAT expression was associated with a poor prognosis in patients with colorectal cancer.[7]

See also

References

Further reading

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