Leiomodin 1

Leiomodin 1 is a protein that in humans is encoded by the LMOD1 gene.^[5]

LMOD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Z79, 4Z8G, 4Z94
Identifiers
Aliases	LMOD1, 1D, 64kD, D1, SM-LMOD, SMLMOD, leiomodin 1, MMIHS3
External IDs	OMIM: 602715; MGI: 2135671; HomoloGene: 8118; GeneCards: LMOD1; OMA:LMOD1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 201,896,456 bp[1] End 201,946,588 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 135,252,545 bp[2] End 135,295,803 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries right coronary artery gastric mucosa Descending thoracic aorta ascending aorta saphenous vein left coronary artery muscle layer of sigmoid colon body of uterus Top expressed in ascending aorta tunica media of zone of aorta aortic valve interventricular septum esophagus urinary bladder uterus left colon tunica adventitia of aorta muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding tropomyosin binding Cellular component cytoskeleton membrane sarcomere myofibril cytoplasm cytosol actin filament striated muscle thin filament Biological process pointed-end actin filament capping actin nucleation positive regulation of actin filament polymerization muscle contraction myofibril assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25802 93689 Ensembl ENSG00000163431 ENSMUSG00000048096 UniProt P29536 Q8BVA4 RefSeq (mRNA) NM_012134 NM_053106 RefSeq (protein) NP_036266 NP_444336 Location (UCSC) Chr 1: 201.9 – 201.95 Mb Chr 1: 135.25 – 135.3 Mb PubMed search [3] [4]
Wikidata
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Function

The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expression of leiomodin 1 may be linked to Graves' disease and thyroid-associated ophthalmopathy. [provided by RefSeq, Jul 2008].