Leucyl-tRNA synthetase

Leucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the LARS gene.^[5][6]

LARS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WFD
Identifiers
Aliases	LARS1, Leucyl-tRNA synthetase, ILFS1, HSPC192, LARS, leucyl-tRNA synthetase 1, LRS, LEUS, LFIS, PIG44, hr025Cl, LEURS, RNTLS
External IDs	OMIM: 151350; MGI: 1913808; HomoloGene: 7083; GeneCards: LARS1; OMA:LARS1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 146,110,566 bp[1] End 146,182,696 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 42,335,363 bp[2] End 42,395,259 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell ventricular zone middle temporal gyrus body of pancreas right uterine tube ganglionic eminence primary visual cortex cartilage tissue islet of Langerhans Top expressed in medullary collecting duct basilar part of occipital bone lacrimal gland yolk sac primitive streak renal corpuscle calvaria seminal vesicula ureter salivary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity nucleotide binding leucine-tRNA ligase activity ligase activity protein binding ATP binding aminoacyl-tRNA editing activity valine-tRNA ligase activity GTPase activator activity glutamine-tRNA ligase activity Cellular component cytosol nuclear body cytoplasm lysosome endoplasmic reticulum endomembrane system aminoacyl-tRNA synthetase multienzyme complex Biological process tRNA aminoacylation for protein translation protein biosynthesis leucyl-tRNA aminoacylation valyl-tRNA aminoacylation protein targeting to lysosome regulation of cell size negative regulation of autophagy cellular response to amino acid starvation positive regulation of GTPase activity cellular response to amino acid stimulus cellular response to leucine positive regulation of TORC1 signaling cellular response to leucine starvation glutaminyl-tRNA aminoacylation aminoacyl-tRNA metabolism involved in translational fidelity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51520 107045 Ensembl ENSG00000133706 ENSMUSG00000024493 UniProt Q9P2J5 Q8BMJ2 RefSeq (mRNA) NM_020117 NM_001317964 NM_001317965 NM_016460 NM_134137 RefSeq (protein) NP_001304893 NP_001304894 NP_057544 NP_064502 NP_598898 Location (UCSC) Chr 5: 146.11 – 146.18 Mb Chr 18: 42.34 – 42.4 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginyl-tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.^[6]

Interactions

Leucyl-tRNA synthetase has been shown to interact with EEF1G.^[7]

Inhibitors

• BC-LI-0186
• Tavaborole^[8]

See also

• Leucine-tRNA ligase