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Linagliptin
Chemical compound From Wikipedia, the free encyclopedia
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Linagliptin, sold under the brand name Tradjenta among others, is a medication used to treat type 2 diabetes (but not type 1) in conjunction with exercise and diet.[7][8] Linagliptin is a dipeptidyl peptidase-4 inhibitor[7] that works by increasing the production of insulin and decreasing the production of glucagon by the pancreas.[7] It is generally less preferred than metformin and sulfonylureas as an initial treatment.[7][9] It is taken by mouth.[7]
Common side effects include inflammation of the nose and throat.[7] Serious side effects may include angioedema, pancreatitis, joint pain.[9][7] Use in pregnancy and breastfeeding is not recommended.[9]
Linagliptin was approved for medical use in the United States,[10] Japan, the European Union, Canada, and Australia in 2011.[7][11] In 2020, it was the 293rd most commonly prescribed medication in the United States, with more than 1 million prescriptions.[12][13] From August 2021 linagliptin became available as a generic medicine in the US.[14]
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Medical uses
Linagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.[5]
Side effects
Mechanism of action
Linagliptin belongs to a class of drugs called DPP-4 inhibitors.[5]
Names
Linagliptin is the international nonproprietary name (INN).[16] Brand names: Trajenta,[17] Tradjenta.
See also
References
External links
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