List of adverse effects of nilotinib

This is a list of adverse effects of the anti-cancer drug nilotinib, sorted by frequency of occurrence.^{[1][2][3][4][5][6]}

Very common

Very common (>10% incidence) adverse effects include:

• Headache
• Nausea
• Hypophosphataemia
• Hyperbilirubinaemia
• Alanine aminotransferase (ALT) increased
• Aspartate aminotransferase increased
• Lipase increased
• Rash
• Itchiness
• Hair loss
• Dry skin
• Muscle aches
• Fatigue

Common

Common (1–10% incidence) adverse effects include:

• Constipation
• Diarrhoea
• Vomiting
• Upper abdominal pain
• Indigestion
• Joint pain
• Muscle spasms
• Pain in extremities
• Asthenia
• Peripheral oedema
• Folliculitis
• Upper respiratory tract infection (including pharyngitis, nasopharyngitis, rhinitis)
• Skin papilloma
• Eosinophilia
• Lymphopenia
• Insomnia
• Anxiety
• Depression
• Diabetes mellitus
• Hypercholesterolaemia
• Hyperlipidaemia
• Hypertriglyceridaemia
• Hyperglycaemia
• Loss of appetite
• Dizziness
• Hypoaesthesia
• Peripheral neuropathy
• Eye pruritus
• Conjunctivitis
• Dry eye (including xerophthalmia)
• Vertigo
• Flushing
• Hypertension
• Angina pectoris
• Arrhythmia (including atrioventricular block, tachycardia, atrial fibrillation, ventricular extrasystoles, bradycardia)
• QT interval prolonged
• Palpitations
• Cough
• Dyspnoea
• Abdominal distension
• Abdominal discomfort
• Taste changes
• Flatulence
• Abnormal liver function
• Bone pain
• Back pain
• Erythema
• Hyperhidrosis
• Contusion
• Acne
• Dermatitis (including allergic, exfoliative and acneiform)
• Night sweats
• Fever without an infectious cause
• Chest pain (including non-cardiac chest pain)
• Chest discomfort
• Decreased haemoglobin
• Increased blood amylase
• Increased blood alkaline phosphatase
• Gamma-glutamyltransferase increased
• Weight increased
• Increased blood insulin
• Increased lipoprotein (including very low density and high density)

Uncommon

Uncommon (0.1–1% incidence) adverse effects include:

• Arteriosclerosis
• Bone marrow suppression
• Both increases and decreases of potassium levels
• Body temperature change sensation (both hot and cold)
• Chills
• Cognitive deficits^[7]
• Conjunctival bleeding and redness
• Cyanosis
• Dental sensitivity to pain
• Bleeding into the lungs^[8]
• Increased blood cholesterol and lipid levels
• Dystonia^[7]
• Erectile dysfunction
• Eyelid swelling
• Flank pain
• Gastritis
• Gout
• Decreased calcium levels
• Jaundice
• Malaise
• Migraine
• Muscle pain and weakness
• Pancreatitis
• Paraesthesia
• Peripheral arterial occlusive disease
• Photopsia
• Pleural effusion
• Skin eruptions
• Skin pain
• Decreased globulins