List of cardiovascular clinical trials

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This is a list of cardiovascular clinical trials, categorized and alphabetized.

Acute coronary syndrome

• International Studies of Infarct Survival (ISIS) - four randomized controlled trials of several drugs for treating suspected acute myocardial infarction.^[1]

Arrhythmias

• Cardiac Arrhythmia Suppression Trial (CAST) - randomized controlled trial designed to test the hypothesis that suppression of premature ventricular complexes (PVC) with class I antiarrhythmic agents after a myocardial infarction (MI) would reduce mortality.^[2][3]

Atrial fibrillation

Coronary artery disease

Epidemiology

• Busselton Health Study - a prospective cohort study of residents of the Western Australian city of Busselton regarding cardiovascular disease, pulmonary function, diabetes, and cancer.^[4]
• Caerphilly Heart Disease Study - prospective cohort study of the residents from Caerphilly, South Wales, to examine relationships between a wide range of social, lifestyle, dietary, and other factors with incident vascular disease.^[5]
• Framingham Heart Study - long-term, ongoing cardiovascular cohort study of residents of the city of Framingham, Massachusetts.^[6]
• Nurses' Health Study - series of prospective studies that examine epidemiology and the long-term effects of nutrition, hormones, environment, and nurses' work-life on health and disease development.^[7]
• Seven Countries Study - a prospective cohort study that examined the relationships between lifestyle, diet, coronary heart disease, and stroke in different populations.^[8]
• Strong Heart Study - cohort study of cardiovascular disease (CVD) and its risk factors among American Indian men and women.^[9]

Heart failure

• Multicenter Automatic Defibrillator Implantation Trial (MADIT) - a series of randomized controlled trials designed to test the hypothesis that implantable cardioverter defibrillator (ICD) therapy in moderately high-risk coronary patients would significantly reduce death.^[10]
• RALES (trial) - randomized controlled trial comparing spironolactone to placebo when added to standard care in patients with advanced heart failure.^[11]

Hypertension

• Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) - a randomized controlled trial of calcium channel blocker, ACE inhibitor, and thiazide diuretic therapy in lowering the incidence of CV events.^[12]
• Systolic Blood Pressure Intervention Trial (SPRINT) - a randomized controlled trial of intensive BP control^[13]

Lipids

• AIM-HIGH (trial) - a randomized controlled trial of niacin for increasing HDL levels.^[14]
• HDL-Atherosclerosis Treatment Study (HATS) - a randomized controlled trial that studied people with coronary heart disease and compared a combination of simvastatin and niacin with antioxidant vitamin therapy.^[15]
• Heart Protection Study - a randomized controlled trial that studied the cholesterol-lowering drug simvastatin and vitamin supplementation in people at risk of cardiovascular disease.^[16]
• JUPITER trial - a randomized controlled trial to evaluate whether statins reduce heart attacks and strokes in people with normal cholesterol levels.^[17]
• PROVE-IT TIMI 22 - a randomized controlled trial that compared intensive vs. moderate-dose statin therapy immediately after a heart attack.^[18]
• Scandinavian Simvastatin Survival Study (4S) - a randomized controlled trial that studied the use of the cholesterol-lowering drug simvastatin in people with moderately raised cholesterol and coronary heart disease.^[19]
• West of Scotland Coronary Prevention Study (WOSCOPS) - a randomized controlled trial that compared the cholesterol-lowering drug pravastatin in patients with no previous history of a heart attack.^[20]

Valvular diseases