List of investigational anxiolytics

This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.

This is a list of investigational anxiolytics, or anxiolytics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

This list was last comprehensively updated in June 2017. It is likely to become outdated with time.

Generalized anxiety disorder

• Riluzole sublingual (BHV-0223) – undefined mechanism of action^[1]
• SPT-320 (LYT-320) – agomelatine prodrug (melatonin receptor agonist and serotonin 5-HT_2B and 5-HT_2C receptor antagonist)^[2][3]
• TGFK08AA – 5-HT_1A receptor modulator^[4]
• TGW00AA (FKW00GA) – 5-HT_1A receptor agonist, 5-HT_2A receptor antagonist ^[5]

Panic disorder

• Darigabat (PF-06372865) – GABA_A receptor positive allosteric modulator^[6]
• Tebideutorexant (JNJ-61393215, JNJ-3215) – orexin OX₁ receptor antagonist^[7]

Post-traumatic stress disorder

• 7-Oxoprasterone (7-keto-DHEA; HBL-9001) – "immunomodulator" / undefined mechanism of action ^[8]
• Brexpiprazole (Lu AF41156, OPC-34712; Rexulti) – atypical antipsychotic / 5-HT_1A, D₂ and D₃ receptor partial agonist and 5-HT_2A, 5-HT_2B, 5-HT₇, α₁-adrenergic, α₂-adrenergic, and H₁ receptor antagonist ^[9]
• Iloperidone (HP-873, ILO-522; Fanapt, Fiapta, Zomaril) – atypical antipsychotic / 5-HT_2A, 5-HT₆, 5-HT₇, D₂, D₃, D₄, and α₁-adrenergic receptor antagonist ^[10]
• MDMA (Midomafetamine, 3,4-methylenedioxymethamphetamine, "ecstasy/molly/E/X") – serotonin–norepinephrine–dopamine releasing agent and 5-HT₁ and 5-HT₂ receptor agonist – specifically under development as an aid to psychotherapy for post-traumatic stress disorder ^[11][12][13]
• NBTX-001 (Xenon) – NMDA receptor antagonist ^[14]
• Pomaglumetad methionil (DB-103, LY-2140023) – mGluR₂ and mGluR₃ agonist ^[15]
• Soclenicant (BNC-210; IW-2143) – "GABATooltip γ-aminobutyric acid modulator"^[16] / undefined mechanism of action^[17][18]
• Tianeptine oxalate/naloxone (TNX-601) – atypical μ-opioid receptor agonist ^[19]

Social anxiety disorder

Main article: List of investigational social anxiety disorder drugs

• Fasedienol (Aloradine; PH94B; 4-androstadienol) – vomeropherine / neurosteroid^[20]
• JNJ-42165279 – FAAH inhibitor^[21][22]
• TGW00AA (FKW00GA) – 5-HT_1A receptor agonist, 5-HT_2A receptor antagonist ^[5]

Others/unspecified

• Brexanolone caprilcerbate (LYT-300, SPT-300) – orally active brexanolone (allopregnanolone) prodrug and GABA_A receptor positive allosteric modulator^[23][24]
• Deuterated etifoxine (GRX-917) – translocator protein (TSPO) agonist and GABA_A receptor positive allosteric modulator^[25][26]
• JNJ-42165279 – FAAH inhibitor^[27]
• JNJ-61393215 – orexin OX₁ receptor antagonist ^[7]
• Maritupirdine (AVN-101; Aviandr) – 5-HT₆ receptor antagonist ^[28]
• MP-20X – CB₁ and 5-HT_1A receptor modulator ^[29]
• Soclenicant (BNC-210; IW-2143) – "GABA modulator"^[16] / undefined mechanism of action / α₇ subunit-containing nicotinic acetylcholine receptor antagonist^[17][18]
• SRX-246 – vasopressin V_1A receptor antagonist ^[30]
• Trideca-7,9,11-trienoic_acid - pharmacological mechanism of action unknown^[31]

See also

• List of investigational drugs
• List of investigational social anxiety disorder drugs