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List of progestogens

From Wikipedia, the free encyclopedia

List of progestogens
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This is a list of progestogens that are or that have been used in clinical or veterinary medicine. They are steroids and include derivatives of progesterone and testosterone.

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Progesterone.
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Steroid ring system.

Progesterone derivatives

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Retroprogesterone derivatives

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Although an active progestogen, retroprogesterone is not medically used.

17α-Hydroxyprogesterone derivatives

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17α-hydroxyprogesterone is inactive as a progestogen and is not used medically.

The 19-norprogesterone derivatives gestonorone caproate (gestronol hexanoate), nomegestrol acetate, segesterone acetate (nestorone, elcometrine), and norgestomet are also derivatives of 17α-hydroxyprogesterone (see below).

17α-Methylprogesterone derivatives

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Although an active progestogen, 17α-methylprogesterone is not medically used.

The 19-norprogesterone derivatives demegestone, promegestone, and trimegestone are also derivatives of 17α-methylprogesterone (see below).

Other 17α-substituted progesterone derivatives

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19-Norprogesterone derivatives

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Although an active progestogen, 19-norprogesterone is not medically used.

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Testosterone derivatives

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Testosterone itself does not have significant progestogenic activity. Testosterone is instead classified as an anabolic-androgenic steroid and is included here purely because it is the parent structure of this group of progestins.

17α-Ethynyltestosterone derivatives

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19-Nortestosterone derivatives

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While nandrolone (19-nortestosterone) does have significant progestogenic activity, it is not used as a progestogen. It is instead classified as an androgenic-anabolic steroid and is included here purely because it is an important parent structure of this group of progestins.

17α-Ethynyl-19-nortestosterone derivatives

Estranes

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18-Methylestranes (13β-ethylgonanes)

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Other 17α-substituted 19-nortestosterone derivatives

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Spirolactone derivatives

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Although an active progestogen, SC-5233 (spirolactone) is not medically used.

See also

Notes

? = Chemical names that are unverified.

Further reading

  • McRobb L, Handelsman DJ, Kazlauskas R, Wilkinson S, McLeod MD, Heather AK (2008). "Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay". J. Steroid Biochem. Mol. Biol. 110 (1–2): 39–47. doi:10.1016/j.jsbmb.2007.10.008. PMID 18395441. S2CID 5612000.
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