Norgestomet

Not to be confused with norgestimate.

Norgestomet, or norgestamet, sold under the brand name Syncro-Mate B and Crestar, is a progestin medication which is used in veterinary medicine to control estrus and ovulation in cattle.^[1][2]

Norgestomet

Clinical data
Trade names	Syncro-Mate B, Crestar
Other names	Norgestamet; SC-21009; 11β-Methyl-17α-acetoxy-19-norprogesterone; 17α-Hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate
Drug class	Progestogen; Progestin; Progestogen ester
Identifiers
IUPAC name [(8R,9S,10R,11S,13S,14S,17R)-17-acetyl-11,13-dimethyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate
CAS Number	25092-41-5
PubChem CID	9820838
ChemSpider	7996587
UNII	3L33UD42X4
CompTox Dashboard (EPA)	DTXSID901016491
ECHA InfoCard	100.042.359
Chemical and physical data
Formula	C23H32O4
Molar mass	372.505 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1CC2(C(CCC2(C(=O)C)OC(=O)C)C3C1C4CCC(=O)C=C4CC3)C
InChI InChI=1S/C23H32O4/c1-13-12-22(4)20(9-10-23(22,14(2)24)27-15(3)25)19-7-5-16-11-17(26)6-8-18(16)21(13)19/h11,13,18-21H,5-10,12H2,1-4H3/t13-,18-,19-,20-,21+,22-,23-/m0/s1 Key:IWSXBCZCPVUWHT-VIFKTUCRSA-N

Uses

Veterinary

Norgestomet is used in veterinary medicine.

Pharmacology

Pharmacodynamics

Norgestomet is a progestogen. In addition to the progesterone receptor, it possesses weak (micromolar) affinity for the glucocorticoid receptor.^[3]

Chemistry

See also: List of progestogens, Progestogen ester, and List of progestogen esters

Norgestomet, also known as 11β-methyl-17α-acetoxy-19-norprogesterone or as 17α-hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate, is a synthetic norpregnane steroid and a derivative of progesterone.^[1][4]

History

Norgestomet was developed and introduced for veterinary use in the mid-1970s.^[5]

Society and culture

Generic names

Norgestomet is the generic name of the drug and its INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, and BANTooltip British Approved Name.^[1][4] It also known as norgestamet and is known by its developmental code name SC-21009.^[1][4][6]

Brand names

Norgestomet is marketed under the brand names Syncro-Mate B and Crestar.^[1][4]