Lymphotoxin beta receptor

Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a cell surface receptor for lymphotoxin involved in apoptosis and cytokine release.^[5][6][7] It is a member of the tumor necrosis factor receptor superfamily.

LTBR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RF3, 4MXW
Identifiers
Aliases	LTBR, CD18, D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFR3, TNFRSF3, lymphotoxin beta receptor
External IDs	OMIM: 600979; MGI: 104875; HomoloGene: 1753; GeneCards: LTBR; OMA:LTBR - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,375,045 bp[1] End 6,391,571 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 59.32 cM Start 125,283,534 bp[2] End 125,290,848 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland minor salivary glands body of pancreas body of stomach upper lobe of left lung muscle layer of sigmoid colon right lobe of liver left uterine tube skin of abdomen Top expressed in granulocyte duodenum gastric mucosa epithelium of stomach yolk sac mucous cell of stomach right kidney saccule membranous bone left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding tumor necrosis factor-activated receptor activity identical protein binding ubiquitin protein ligase binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane Golgi apparatus Biological process myeloid dendritic cell differentiation tumor necrosis factor-mediated signaling pathway positive regulation of JNK cascade multicellular organism development cellular response to mechanical stimulus response to lipopolysaccharide regulation of cell population proliferation positive regulation of extrinsic apoptotic signaling pathway inflammatory response viral process signal transduction apoptotic process immune response positive regulation of I-kappaB kinase/NF-kappaB signaling hematopoietic or lymphoid organ development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4055 17000 Ensembl ENSG00000111321 ENSMUSG00000030339 UniProt P36941 P50284 RefSeq (mRNA) NM_001270987 NM_002342 NM_010736 RefSeq (protein) NP_001257916 NP_002333 NP_034866 Location (UCSC) Chr 12: 6.38 – 6.39 Mb Chr 6: 125.28 – 125.29 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphotoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis.^[5]

Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. LTBR is also essential for development and organization of the secondary lymphoid organs and chemokine release.^[8]

Structure

The Ramachandran plots show that 64.6% of all residues were in a favored region. This structure was found using X-ray diffraction. The resolution is 3.50 angstroms. The alpha and beta angles are 90 degrees while the gamma angle is 120 degrees.^[9]

Interactions

Lymphotoxin beta receptor has been shown to interact with Diablo homolog^[10] and TRAF3.^[11][12][13]