Lysophosphatidylserine

A lysophosphatidylserine is a lysophospholipid. Various lysophosphatidylserines trigger TLR 2.^[1] They can also modulate T cell function via suppression of Interleukin_2 (IL-2) production in CD4 T cells.^[2] They can also trigger mast cell degranulation.^[3] They interact with three G protein-coupled receptors (GPCRs), LPS1/GPR34, LPS2/P2Y10, and LPS3/GPR174.^[2]

A recent study showed that lysophosphatidylserines do not stimulate normal leukocytes.^[4] They also enhances glucose transport, lowering blood glucose levels while leaving secretion of insulin unaffected.^[5]