GPR34

Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.^[5][6][7] The receptor binds to lysophosphatidylserine. ^[8]

GPR34
Identifiers
Aliases	GPR34, LYPSR1, G protein-coupled receptor 34
External IDs	OMIM: 300241; MGI: 1346334; HomoloGene: 36174; GeneCards: GPR34; OMA:GPR34 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.4 Start 41,688,973 bp[1] End 41,697,275 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A1.1 Start 13,498,328 bp[2] End 13,507,097 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon smooth muscle tissue testicle placenta mucosa of ileum right coronary artery appendix gallbladder rectum monocyte Top expressed in lumbar subsegment of spinal cord stroma of bone marrow dentate gyrus of hippocampal formation granule cell mesenteric lymph nodes Region I of hippocampus proper superior frontal gyrus primary visual cortex spleen ankle embryo More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled purinergic nucleotide receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2857 23890 Ensembl ENSG00000171659 ENSMUSG00000040229 UniProt Q9UPC5 Q9R1K6 RefSeq (mRNA) NM_001033513 NM_001033514 NM_001097579 NM_005300 NM_011823 RefSeq (protein) NP_001091048 NP_005291 NP_035953 Location (UCSC) Chr X: 41.69 – 41.7 Mb Chr X: 13.5 – 13.51 Mb PubMed search [3] [4]
Wikidata
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Function

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM]^[7]