MAD2L1BP

MAD2L1-binding protein is a protein that in humans is encoded by the MAD2L1BP gene.^[5][6][7]

MAD2L1BP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QYF
Identifiers
Aliases	MAD2L1BP, CMT2, MAD2L1 binding protein
External IDs	OMIM: 618136; MGI: 1913841; HomoloGene: 11990; GeneCards: MAD2L1BP; OMA:MAD2L1BP - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 43,629,540 bp[1] End 43,640,941 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 46,458,313 bp[2] End 46,464,479 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon oocyte rectum islet of Langerhans gastrocnemius muscle granulocyte monocyte left ventricle apex of heart olfactory zone of nasal mucosa Top expressed in Ileal epithelium morula morula soleus muscle fetal liver hematopoietic progenitor cell blastocyst yolk sac granulocyte sternocleidomastoid muscle temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm spindle cytoskeleton nucleus nucleolus nuclear membrane Biological process regulation of exit from mitosis mitotic cell cycle checkpoint signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9587 66591 Ensembl ENSG00000124688 ENSMUSG00000034509 UniProt Q15013 Q9DCX1 RefSeq (mRNA) NM_014628 NM_001003690 NM_025649 RefSeq (protein) NP_001003690 NP_055443 NP_079925 Location (UCSC) Chr 6: 43.63 – 43.64 Mb Chr 17: 46.46 – 46.46 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.^[7]

Interactions

MAD2L1BP has been shown to interact with TRIP13.^[8][9]