MAGEB2

Melanoma-associated antigen B2 is a protein that in humans is encoded by the MAGEB2 gene.^[5][6]

MAGEB2
Identifiers
Aliases	MAGEB2, CT3.2, DAM6, MAGE-XP-2, MAGE family member B2
External IDs	OMIM: 300098; MGI: 2148568; HomoloGene: 134515; GeneCards: MAGEB2; OMA:MAGEB2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp21.2 Start 30,215,563 bp[1] End 30,220,089 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C1 Start 85,293,860 bp[2] End 85,348,699 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad right testis left testis pancreatic ductal cell skin of hip optic nerve skin of thigh lower lobe of lung placenta Top expressed in embryo morula embryo spermatid spermatocyte testicle epiblast More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 4113 434903 Ensembl ENSG00000099399 ENSMUSG00000035427 UniProt O15479 A2A9R3 RefSeq (mRNA) NM_002364 NM_001033492 RefSeq (protein) NP_002355 NP_001028664 Location (UCSC) Chr X: 30.22 – 30.22 Mb Chr X: 85.29 – 85.35 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.^[6]