MAGI2

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene.^[5][6][7]

MAGI2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UEP, 1UEQ, 1UEW, 1UJV, 1WFV
Identifiers
Aliases	MAGI2, ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM, membrane associated guanylate kinase, WW and PDZ domain containing 2, NPHS15
External IDs	OMIM: 606382; MGI: 1354953; HomoloGene: 8189; GeneCards: MAGI2; OMA:MAGI2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.11 Start 78,017,055 bp[1] End 79,453,667 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A3 Start 19,432,034 bp[2] End 20,909,790 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum Brodmann area 23 middle temporal gyrus glomerulus metanephric glomerulus Brodmann area 46 Parietal Lobe entorhinal cortex postcentral gyrus Top expressed in Rostral migratory stream primary motor cortex cingulate gyrus substantia nigra Region I of hippocampus proper nucleus accumbens globus pallidus primary visual cortex sciatic nerve arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity SMAD binding phosphatase binding beta-1 adrenergic receptor binding molecular adaptor activity type II activin receptor binding signaling receptor complex adaptor activity protein binding activin receptor binding kinase activity Cellular component late endosome cytoplasm synapse cell junction nucleus neuron projection postsynaptic density membrane dendrite perinuclear region of cytoplasm slit diaphragm bicellular tight junction plasma membrane endosome protein-containing complex cell-cell junction Biological process receptor clustering negative regulation of cell population proliferation positive regulation of neuron projection development neuroligin clustering involved in postsynaptic membrane assembly signal transduction negative regulation of activin receptor signaling pathway nerve growth factor signaling pathway planar cell polarity pathway involved in axis elongation SMAD protein signal transduction positive regulation of receptor internalization protein heterooligomerization negative regulation of protein kinase B signaling nervous system development glomerular visceral epithelial cell development positive regulation of synaptic vesicle clustering cellular response to nerve growth factor stimulus positive regulation of phosphoprotein phosphatase activity negative regulation of cell migration positive regulation of signal transduction phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9863 50791 Ensembl ENSG00000187391 ENSMUSG00000040003 UniProt Q86UL8 Q9WVQ1 RefSeq (mRNA) NM_001301128 NM_012301 NM_001170745 NM_001170746 NM_015823 RefSeq (protein) NP_001288057 NP_036433 NP_001164216 NP_001164217 NP_056638 Location (UCSC) Chr 7: 78.02 – 79.45 Mb Chr 5: 19.43 – 20.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral-pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.^[7]

Interactions

MAGI2 has been shown to interact with ATN1^[8] and PTEN (gene).