MAGOH

Protein mago nashi homolog is a human protein encoded by the MAGOH gene.^[5][6] This gene encodes the mammalian homolog of the Drosophila mago nashi gene. In mammals, mRNA expression is not limited to the germplasm, but is ubiquitous in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.

MAGOH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P27, 2HYI, 2J0Q, 2J0S, 2XB2, 3EX7
Identifiers
Aliases	MAGOH, MAGOH1, MAGOHA, mago homolog, exon junction complex core component, mago homolog, exon junction complex subunit
External IDs	OMIM: 602603; MGI: 1330312; HomoloGene: 1776; GeneCards: MAGOH; OMA:MAGOH - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 53,226,900 bp[1] End 53,238,518 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C7|4 50.18 cM Start 107,736,952 bp[2] End 107,744,621 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte monocyte olfactory zone of nasal mucosa rectum mucosa of transverse colon left lobe of thyroid gland ventricular zone body of uterus granulocyte Top expressed in zygote secondary oocyte yolk sac epiblast embryo ventricular zone embryo placenta morula primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasm nuclear speck catalytic step 2 spliceosome exon-exon junction complex nucleoplasm spliceosomal complex nucleus Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA transport mRNA processing regulation of alternative mRNA splicing, via spliceosome mRNA export from nucleus nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA 3'-end processing regulation of translation RNA splicing RNA export from nucleus transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4116 17149 Ensembl ENSG00000162385 ENSMUSG00000028609 UniProt P61326 P61327 RefSeq (mRNA) NM_002370 NM_001282737 RefSeq (protein) NP_002361 NP_001269666 Location (UCSC) Chr 1: 53.23 – 53.24 Mb Chr 4: 107.74 – 107.74 Mb PubMed search [3] [4]
Wikidata
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In Drosophila

Drosophila flies produce unfit progeny when they have mutations in their mago nashi (Japanese: 孫なし, Hepburn: mago nashi; lit. 'grandchildless') gene. The progeny have defects in germplasm assembly and germline development.^[6]

Interactions

MAGOH interacts with RBM8A^[7][8] and NXF1.^[8]

In Drosophila melanogaster, Mago Nashi and Tsunagi/Y14 are core components of the exon junction complex. They complex with novel zinc finger protein Ranshi, which is involved in oocyte differentiation.^[9]