MALAT1

MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) also known as NEAT2 (Nuclear-Enriched Abundant Transcript 2) is an infrequently spliced long non-coding RNA, which is highly conserved amongst mammals and highly expressed in the nucleus.^[3] It regulates the expression of metastasis-associated genes.^[4] It also positively regulates cell motility via the transcriptional and/or post-transcriptional regulation of motility-related genes.^[5] MALAT1 may play a role in temperature-dependent sex determination in the Red-eared slider turtle (Trachemys scripta).^[6]

MALAT1
Identifiers
Aliases	MALAT1, HCN, LINC00047, MALAT-1, NCRNA00047, NEAT2, PRO2853, mascRNA, metastasis associated lung adenocarcinoma transcript 1 (non-protein coding), metastasis associated lung adenocarcinoma transcript 1
External IDs	OMIM: 607924; GeneCards: MALAT1; OMA:MALAT1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,497,688 bp[1] End 65,506,516 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla trigeminal ganglion cardia corpus callosum pylorus seminal vesicula Achilles tendon external globus pallidus spinal ganglia pars compacta n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 378938 n/a Ensembl ENSG00000251562 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 11: 65.5 – 65.51 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Conserved secondary structure in Metastasis associated lung adenocarcinoma transcript 1
Predicted secondary structure and sequence conservation of MALAT1
Identifiers
Symbol	MALAT1
Rfam	RF01871
Other data
RNA type	Gene;
Domain(s)	Eukaryota;
GO	GO:2000147
SO	SO:0001263
PDB structures	PDBe

Expression in alcoholic brains

Transcripts of MALAT1 are significantly increased in the cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. This alcohol-induced upregulation of MALAT1 may be responsible for differential expression of a number of proteins which contribute to ethanol tolerance and dependency in humans.^[7]

Prognostic potential in cancer

Elevated MALAT1 expression is correlated with poor overall survival in various types of cancer, suggesting that this gene is a prognostic factor for different types of cancer.^[8][9]

See also

• Long non-coding RNA
• MALAT1-associated small cytoplasmic RNA