MALL

MAL-like protein is a protein that in humans is encoded by the MALL gene.^[5][6]

MALL
Identifiers
Aliases	MALL, BENE, mal, T-cell differentiation protein like, mal, T cell differentiation protein like
External IDs	OMIM: 602022; MGI: 2385152; HomoloGene: 3965; GeneCards: MALL; OMA:MALL - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q13 Start 110,083,870 bp[1] End 110,116,022 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 127,546,306 bp[2] End 127,571,852 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum mucosa of transverse colon epithelium of bronchus rectum vagina skin of leg upper lobe of left lung skin of abdomen islet of Langerhans tonsil Top expressed in esophagus intestinal villus duodenum ileum jejunum lip conjunctival fornix large intestine colon left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of myelin sheath Cellular component Golgi membrane clathrin-coated vesicle plasma membrane membrane membrane raft integral component of membrane cytoplasmic vesicle Biological process cholesterol homeostasis membrane raft polarization protein localization myelination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7851 228576 Ensembl ENSG00000144063 ENSMUSG00000027377 UniProt Q13021 Q91X49 RefSeq (mRNA) NM_005434 NM_001371559 NM_001371560 NM_145532 RefSeq (protein) NP_005425 NP_001358488 NP_001358489 NP_663507 Location (UCSC) Chr 2: 110.08 – 110.12 Mb Chr 2: 127.55 – 127.57 Mb PubMed search [3] [4]
Wikidata
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For other uses, see Mall.

This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid-enriched membrane (GEM) and cholesterol-enriched membrane rafts. It interacts with caveolin-1.^[6]