MAN1A1

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA is an enzyme that in humans is encoded by the MAN1A1 gene.^[5][6]

MAN1A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NXC
Identifiers
Aliases	MAN1A1, HUMM3, HUMM9, MAN9, mannosidase alpha class 1A member 1
External IDs	OMIM: 604344; MGI: 104677; HomoloGene: 4316; GeneCards: MAN1A1; OMA:MAN1A1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.31 Start 119,177,205 bp[1] End 119,349,761 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B3 Start 53,780,881 bp[2] End 53,952,705 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint renal medulla pericardium jejunal mucosa lower lobe of lung urethra parotid gland palpebral conjunctiva Achilles tendon skin of hip Top expressed in parotid gland mesenteric lymph nodes lateral septal nucleus vestibular membrane of cochlear duct retinal pigment epithelium lacrimal gland epithelium of stomach otic placode submandibular gland spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding hydrolase activity mannosidase activity hydrolase activity, acting on glycosyl bonds mannosyl-oligosaccharide 1,2-alpha-mannosidase activity catalytic activity Cellular component integral component of membrane Golgi membrane Golgi apparatus extracellular exosome endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment cytosol Biological process protein glycosylation N-glycan processing metabolism Golgi apparatus mannose trimming Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4121 17155 Ensembl ENSG00000111885 ENSMUSG00000003746 UniProt P33908 P45700 RefSeq (mRNA) NM_005907 NM_008548 RefSeq (protein) NP_005898 NP_032574 Location (UCSC) Chr 6: 119.18 – 119.35 Mb Chr 10: 53.78 – 53.95 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the removal of 3 distinct mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases.^[6]