MAN1B1

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase is an enzyme that in humans is encoded by the MAN1B1 gene.^[5][6][7]

MAN1B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FMI, 1FO2, 1FO3, 1X9D
Identifiers
Aliases	MAN1B1, ERMAN1, MANA-ER, MRT15, ERManI, mannosidase alpha class 1B member 1
External IDs	OMIM: 604346; MGI: 2684954; HomoloGene: 5230; GeneCards: MAN1B1; OMA:MAN1B1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,086,857 bp[1] End 137,109,189 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,222,350 bp[2] End 25,242,224 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right uterine tube skin of leg anterior pituitary apex of heart skin of abdomen right hemisphere of cerebellum minor salivary glands olfactory zone of nasal mucosa right lobe of thyroid gland Top expressed in spermatocyte Ileal epithelium spermatid neural layer of retina yolk sac corneal stroma granulocyte ventricular zone dentate gyrus of hippocampal formation granule cell superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding calcium ion binding hydrolase activity, acting on glycosyl bonds hydrolase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity catalytic activity Cellular component extracellular vesicle integral component of membrane Golgi apparatus membrane endoplasmic reticulum membrane endoplasmic reticulum endoplasmic reticulum quality control compartment Golgi membrane Biological process oligosaccharide metabolic process metabolism N-glycan processing mannose trimming involved in glycoprotein ERAD pathway protein alpha-1,2-demannosylation protein glycosylation ubiquitin-dependent ERAD pathway trimming of terminal mannose on B branch trimming of terminal mannose on C branch trimming of first mannose on A branch trimming of second mannose on A branch endoplasmic reticulum mannose trimming Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11253 227619 Ensembl ENSG00000177239 ENSMUSG00000036646 UniProt Q9UKM7 A2AJ15 RefSeq (mRNA) NM_016219 NM_001029983 RefSeq (protein) NP_057303 NP_001025154 Location (UCSC) Chr 9: 137.09 – 137.11 Mb Chr 2: 25.22 – 25.24 Mb PubMed search [3] [4]
Wikidata
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