MAP1B

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.^[5][6]

MAP1B
Identifiers
Aliases	MAP1B, FUTSCH, MAP5, PPP1R102, microtubule-associated protein 1B, microtubule associated protein 1B, PVNH9, DFNA83
External IDs	OMIM: 157129; MGI: 1306778; HomoloGene: 38111; GeneCards: MAP1B; OMA:MAP1B - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.2 Start 72,107,234 bp[1] End 72,209,565 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D1|13 52.9 cM Start 99,557,954 bp[2] End 99,653,048 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus pars compacta middle temporal gyrus pars reticulata Brodmann area 23 superior vestibular nucleus pons external globus pallidus parietal lobe postcentral gyrus Top expressed in facial motor nucleus anterior horn of spinal cord median eminence substantia nigra medial dorsal nucleus habenula medial vestibular nucleus Rostral migratory stream pontine nuclei medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding structural molecule activity protein binding actin binding tubulin binding phospholipid binding protein-containing complex binding Cellular component cell projection postsynaptic density plasma membrane dendritic spine photoreceptor outer segment synapse microtubule associated complex cell junction microtubule cytoskeleton cytoplasm cytosol axon dendrite somatodendritic compartment soma apical dendrite basal dendrite hippocampal mossy fiber growth cone varicosity perikaryon perinuclear region of cytoplasm Biological process negative regulation of intracellular transport axonogenesis dendrite development nervous system development microtubule bundle formation axon extension positive regulation of axon extension mitochondrion transport along microtubule establishment of monopolar cell polarity cellular process or phenomenon microtubule cytoskeleton organization neuron migration regulation of microtubule depolymerization negative regulation of microtubule depolymerization synapse assembly response to wounding response to mechanical stimulus response to carbohydrate response to inorganic substance peripheral nervous system axon regeneration response to insecticide developmental maturation positive regulation of microtubule polymerization response to nutrient levels response to estradiol response to vitamin A positive regulation of neuron differentiation neuron development response to axon injury induction of synaptic plasticity by chemical substance cellular response to growth factor stimulus cellular response to peptide hormone stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4131 17755 Ensembl ENSG00000131711 ENSMUSG00000052727 UniProt P46821 P14873 RefSeq (mRNA) NM_005909 NM_032010 NM_001324255 NM_008634 RefSeq (protein) NP_001311184 NP_005900 NP_032660 Location (UCSC) Chr 5: 72.11 – 72.21 Mb Chr 13: 99.56 – 99.65 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.^[6]

Interactions

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A^[7] and RASSF1.^[8]