MAP2K6

Main article: Mitogen-activated protein kinase kinase

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.^[5]

MAP2K6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y8O, 3ENM, 3FME, 3VN9
Identifiers
Aliases	MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, mitogen-activated protein kinase kinase 6
External IDs	OMIM: 601254; MGI: 1346870; HomoloGene: 55686; GeneCards: MAP2K6; OMA:MAP2K6 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q24.3 Start 69,414,697 bp[1] End 69,553,865 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1-E2 Start 110,399,122 bp[2] End 110,525,522 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum mucosa of transverse colon biceps brachii vastus lateralis muscle Skeletal muscle tissue of biceps brachii gastrocnemius muscle triceps brachii muscle deltoid muscle Skeletal muscle tissue of rectus abdominis muscle of thigh Top expressed in triceps brachii muscle temporal muscle muscle of thigh sternocleidomastoid muscle maxillary prominence somite mandibular prominence vastus lateralis muscle tail of embryo gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding protein tyrosine kinase activity ATP binding protein kinase binding protein serine/threonine kinase activity identical protein binding MAP kinase kinase activity Cellular component cytoplasm nucleoplasm cytoskeleton nucleus cytosol Biological process positive regulation of protein phosphorylation regulation of transcription, DNA-templated cardiac muscle contraction phosphorylation cellular response to sorbitol positive regulation of nitric-oxide synthase biosynthetic process ovulation cycle process transcription, DNA-templated MAPK cascade protein phosphorylation positive regulation of prostaglandin secretion response to ischemia DNA damage induced protein phosphorylation positive regulation of apoptotic process peptidyl-tyrosine phosphorylation nucleotide-binding oligomerization domain containing signaling pathway signal transduction apoptotic process regulation of mitotic cell cycle stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of apoptotic process negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5608 26399 Ensembl ENSG00000108984 ENSMUSG00000020623 UniProt P52564 P70236 RefSeq (mRNA) NM_002758 NM_031988 NM_001330450 NM_011943 RefSeq (protein) NP_001317379 NP_002749 NP_036073 NP_001343274 NP_001343275 NP_001343276 NP_001343281 NP_001343282 Location (UCSC) Chr 17: 69.41 – 69.55 Mb Chr 11: 110.4 – 110.53 Mb PubMed search [3] [4]
Wikidata
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Function

MAPKK 6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress-induced cell cycle arrest, transcription activation and apoptosis.^[6]

Interactions

MAP2K6 has been shown to interact with TAOK2,^[7] ASK1,^[8][9] MAPK14^{[7][10][11][12]} and MAP3K7.^{[13][14][15][16]}