MAPRE2

Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2 gene.^[5][6][7]

MAPRE2
Identifiers
Aliases	MAPRE2, EB1, EB2, RP1, CSCSC2, microtubule associated protein RP/EB family member 2
External IDs	OMIM: 605789; MGI: 106271; HomoloGene: 75027; GeneCards: MAPRE2; OMA:MAPRE2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.1-q12.2 Start 34,976,928 bp[1] End 35,143,470 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 A2|18 12.08 cM Start 23,885,390 bp[2] End 24,026,918 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spinal ganglia corpus callosum inferior ganglion of vagus nerve C1 segment parietal lobe prefrontal cortex subthalamic nucleus postcentral gyrus entorhinal cortex pons Top expressed in Rostral migratory stream nucleus accumbens motor neuron ciliary body barrel cortex iris substantia nigra retinal pigment epithelium dorsal striatum external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding protein binding identical protein binding protein kinase binding microtubule plus-end binding Cellular component microtubule cytoskeleton microtubule plus-end microtubule cytoskeleton cytoplasm microtubule organizing center cytoplasmic microtubule focal adhesion spindle midzone Biological process cell cycle cell population proliferation signal transduction cell division regulation of microtubule polymerization or depolymerization positive regulation of ARF protein signal transduction protein localization to microtubule positive regulation of GTPase activity spindle assembly positive regulation of keratinocyte migration positive regulation of adherens junction organization protein localization to microtubule plus-end Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10982 212307 Ensembl ENSG00000166974 ENSMUSG00000024277 UniProt Q15555 Q8R001 RefSeq (mRNA) NM_001143826 NM_001143827 NM_001256420 NM_014268 NM_001162941 NM_001162942 NM_153058 RefSeq (protein) NP_001137298 NP_001137299 NP_001243349 NP_055083 NP_001156413 NP_001156414 NP_694698 Location (UCSC) Chr 18: 34.98 – 35.14 Mb Chr 18: 23.89 – 24.03 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.^[7]

Interactions

MAPRE2 has been shown to interact with APC.^[8][9]