MAPRE3

Microtubule-associated protein RP/EB family member 3 is a protein that in humans is encoded by the MAPRE3 gene.^[5][6]

MAPRE3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WYO, 3CO1, 3JAK, 3JAL, 3JAR, 3TQ7
Identifiers
Aliases	MAPRE3, EB3, EBF3, EBF3-S, RP3, microtubule associated protein RP/EB family member 3
External IDs	OMIM: 605788; MGI: 2140967; HomoloGene: 56565; GeneCards: MAPRE3; OMA:MAPRE3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 26,970,637 bp[1] End 27,027,219 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 30,971,985 bp[2] End 31,023,450 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 right hemisphere of cerebellum right frontal lobe right uterine tube middle frontal gyrus paraflocculus of cerebellum frontal pole cingulate gyrus anterior cingulate cortex anterior pituitary Top expressed in neural layer of retina superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell muscle of thigh perirhinal cortex cerebellar cortex CA3 field spermatid entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding protein binding identical protein binding protein C-terminus binding protein kinase binding microtubule plus-end binding Cellular component microtubule cytoskeleton microtubule plus-end perinuclear region of cytoplasm cytoplasmic microtubule midbody microtubule cytoskeleton cytoplasm microtubule organizing center spindle midzone mitotic spindle astral microtubule end Biological process positive regulation of transcription, DNA-templated cell cycle positive regulation of microtubule plus-end binding positive regulation of cyclin-dependent protein serine/threonine kinase activity cell division protein localization regulation of microtubule polymerization or depolymerization protein localization to microtubule positive regulation of protein kinase activity spindle assembly protein localization to microtubule plus-end Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22924 100732 Ensembl ENSG00000084764 ENSMUSG00000029166 UniProt Q9UPY8 Q6PER3 RefSeq (mRNA) NM_001303050 NM_012326 NM_133350 NM_001310516 RefSeq (protein) NP_001289979 NP_036458 NP_001297445 NP_579928 Location (UCSC) Chr 2: 26.97 – 27.03 Mb Chr 5: 30.97 – 31.02 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene.^[6]