MARCH6

E3 ubiquitin-protein ligase MARCH6 is an enzyme that in humans is encoded by the MARCH6 gene.^[5][6]

MARCHF6
Identifiers
Aliases	MARCHF6, DOA10, MARCH-VI, RNF176, TEB4, membrane associated ring-CH-type finger 6, MARCH6, FAME3
External IDs	OMIM: 613297; MGI: 2442773; HomoloGene: 4301; GeneCards: MARCHF6; OMA:MARCHF6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.2 Start 10,353,695 bp[1] End 10,440,388 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B2 Start 31,456,037 bp[2] End 31,531,199 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell glutes Region I of hippocampus proper middle temporal gyrus cerebellar vermis dorsal motor nucleus of vagus nerve corpus callosum pons postcentral gyrus Top expressed in extensor digitorum longus muscle cingulate gyrus plantaris muscle lateral septal nucleus median eminence ventromedial nucleus subiculum arcuate nucleus amygdala anterior amygdaloid area More reference expression data BioGPS n/a
Gene ontology Molecular function enzyme binding ubiquitin-specific protease binding zinc ion binding ubiquitin conjugating enzyme binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity transferase activity protein binding Cellular component integral component of membrane integral component of endoplasmic reticulum membrane ER ubiquitin ligase complex membrane endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum quality control compartment Biological process protein K48-linked ubiquitination proteasomal protein catabolic process ERAD pathway protein ubiquitination endoplasmic reticulum mannose trimming ubiquitin-dependent ERAD pathway proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10299 223455 Ensembl ENSG00000145495 ENSMUSG00000039100 UniProt O60337 Q6ZQ89 RefSeq (mRNA) NM_001270660 NM_001270661 NM_005885 NM_172606 RefSeq (protein) NP_001257589 NP_001257590 NP_005876 NP_766194 NP_001389808 Location (UCSC) Chr 5: 10.35 – 10.44 Mb Chr 15: 31.46 – 31.53 Mb PubMed search [3] [4]
Wikidata
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Gene name error in Excel

Main article: Microsoft Excel § Conversion_problems

Like the other MARCH and septin genes, care must be exercised when analyzing genetic data containing the MARCH6 gene in Microsoft Excel.^[7] This is due to Excel's autocorrect feature treating the text "MARCH6" as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error.^[8] The issue can be prevented by using an alias name (such as MARCHF6), prepending with an apostrophe ('), or preformatting the cell as text.

See also

• Biology portal

• List of EC numbers (EC 3)