MARCH7

E3 ubiquitin-protein ligase MARCH7 is an enzyme that in humans is encoded by the MARCH7 gene.^[4][5]

MARCHF7
Identifiers
Aliases	MARCHF7, AXO, AXOT, MARCH-VII, RNF177, membrane associated ring-CH-type finger 7, MARCH7
External IDs	OMIM: 613334; MGI: 1931053; HomoloGene: 10753; GeneCards: MARCHF7; OMA:MARCHF7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.2 Start 159,712,457 bp[1] End 159,771,027 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon amniotic fluid ventricular zone gingival epithelium secondary oocyte oral cavity germinal epithelium ganglionic eminence gallbladder epithelium of nasopharynx n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding transferase activity enzyme binding ubiquitin conjugating enzyme binding ubiquitin binding MDM2/MDM4 family protein binding protein binding Cellular component nucleus cytosol plasma membrane Biological process negative regulation of T cell proliferation regulation of tolerance induction protein ubiquitination positive regulation of cell population proliferation negative regulation of DNA damage response, signal transduction by p53 class mediator protein stabilization protein autoubiquitination negative regulation of proteasomal protein catabolic process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of protein polyubiquitination negative regulation of protein autoubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64844 57438 Ensembl ENSG00000136536 n/a UniProt Q9H992 Q9WV66 RefSeq (mRNA) NM_001282805 NM_001282806 NM_001282807 NM_022826 NM_020575 RefSeq (protein) NP_001269734 NP_001269735 NP_001269736 NP_073737 NP_001363163 NP_001363164 NP_001363165 NP_001363166 NP_001363167 NP_001363168 NP_001363169 NP_001363170 NP_001363171 NP_001363172 NP_001363173 NP_001363174 NP_001363175 NP_001363176 NP_001363177 NP_001363178 NP_001363179 NP_001363180 NP_001363181 NP_001363182 NP_001363183 NP_001363184 NP_065600 Location (UCSC) Chr 2: 159.71 – 159.77 Mb n/a PubMed search [2] [3]
Wikidata
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