MARK1

Serine/threonine-protein kinase MARK1 is an enzyme that in humans is encoded by the MARK1 gene.^[5][6]

MARK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HAK, 3OSE
Identifiers
Aliases	MARK1, MARK, Par-1c, Par1c, microtubule affinity regulating kinase 1
External IDs	OMIM: 606511; MGI: 2664902; HomoloGene: 49552; GeneCards: MARK1; OMA:MARK1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q41 Start 220,528,136 bp[1] End 220,664,461 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H5 Start 184,628,986 bp[2] End 184,731,767 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone corpus epididymis pons cerebellar vermis Brodmann area 23 superior frontal gyrus spinal ganglia endothelial cell primary visual cortex Top expressed in trigeminal ganglion motor neuron barrel cortex substantia nigra fossa external carotid artery condyle internal carotid artery tunica media of zone of aorta ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity phosphatidylserine binding metal ion binding kinase activity phosphatidic acid binding protein serine/threonine kinase activity tau-protein kinase activity phosphatidylinositol-4,5-bisphosphate binding ATP binding magnesium ion binding lipid binding protein binding tau protein binding Cellular component cytoplasm membrane microtubule cytoskeleton plasma membrane cytoskeleton dendrite cell projection Biological process intracellular signal transduction phosphorylation neuron migration Wnt signaling pathway protein phosphorylation cytoskeleton organization establishment of cell polarity microtubule cytoskeleton organization regulation of neuron projection development peptidyl-serine phosphorylation regulation of dendrite development establishment of mitochondrion localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4139 226778 Ensembl ENSG00000116141 ENSMUSG00000026620 UniProt Q9P0L2 Q8VHJ5 RefSeq (mRNA) NM_001286124 NM_001286126 NM_001286128 NM_001286129 NM_018650 NM_145515 NM_001378876 RefSeq (protein) NP_001273053 NP_001273055 NP_001273057 NP_001273058 NP_061120 NP_663490 NP_001365805 Location (UCSC) Chr 1: 220.53 – 220.66 Mb Chr 1: 184.63 – 184.73 Mb PubMed search [3] [4]
Wikidata
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