MARK2

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene.^[5][6][7]

MARK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IEC, 5EAK
Identifiers
Aliases	MARK2, EMK-1, EMK1, PAR-1, Par-1b, Par1b, microtubule affinity regulating kinase 2
External IDs	OMIM: 600526; MGI: 99638; HomoloGene: 69013; GeneCards: MARK2; OMA:MARK2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 63,838,928 bp[1] End 63,911,020 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 5.32 cM Start 7,252,761 bp[2] End 7,319,225 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte skin of abdomen mucosa of transverse colon skin of leg monocyte rectum minor salivary glands islet of Langerhans right hemisphere of cerebellum apex of heart Top expressed in Ileal epithelium zygote corneal stroma superior surface of tongue CA3 field lactiferous gland cardiac muscle tissue of left ventricle granulocyte plantaris muscle secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein kinase activator activity metal ion binding kinase activity protein serine/threonine kinase activity tau-protein kinase activity protein binding ATP binding magnesium ion binding lipid binding RNA binding cadherin binding tau protein binding Cellular component microtubule bundle cytoplasm lateral plasma membrane membrane plasma membrane mitochondrion actin filament cytoskeleton nucleoplasm dendrite cell projection Biological process cell differentiation intracellular signal transduction phosphorylation mitochondrion localization neuron migration Wnt signaling pathway regulation of axonogenesis multicellular organism development protein phosphorylation autophagy of mitochondrion establishment or maintenance of epithelial cell apical/basal polarity positive regulation of neuron projection development protein autophosphorylation peptidyl-threonine phosphorylation activation of protein kinase activity regulation of cytoskeleton organization establishment of cell polarity microtubule cytoskeleton organization peptidyl-serine phosphorylation axon development regulation of microtubule cytoskeleton organization establishment or maintenance of cell polarity regulating cell shape regulation of microtubule binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2011 13728 Ensembl ENSG00000072518 ENSMUSG00000024969 UniProt Q7KZI7 Q05512 RefSeq (mRNA) NM_001039469 NM_001163296 NM_001163297 NM_004954 NM_017490 NM_001080388 NM_001080389 NM_001080390 NM_007928 RefSeq (protein) NP_001034558 NP_001156768 NP_001156769 NP_004945 NP_059672 NP_001073857 NP_001073858 NP_001073859 NP_031954 Location (UCSC) Chr 11: 63.84 – 63.91 Mb Chr 19: 7.25 – 7.32 Mb PubMed search [3] [4]
Wikidata
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Function

EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.^[7]

Interactions

MARK2 has been shown to interact with AKT1.^[8]