MARK3

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.^[5][6]

MARK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QNJ, 3FE3
Identifiers
Aliases	MARK3, CTAK1, KP78, PAR1A, Par-1a, microtubule affinity regulating kinase 3, VIPB
External IDs	OMIM: 602678; MGI: 1341865; HomoloGene: 55653; GeneCards: MARK3; OMA:MARK3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.32-q32.33 Start 103,385,377 bp[1] End 103,503,831 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F1 Start 111,540,957 bp[2] End 111,622,655 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum body of pancreas apex of heart right adrenal cortex left uterine tube right lung right auricle of heart left adrenal gland left adrenal cortex Top expressed in genital tubercle tail of embryo ventricular zone spermatid molar right kidney proximal tubule Gonadal ridge otic vesicle ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding ATP binding protein serine/threonine kinase activity tau protein binding tau-protein kinase activity Cellular component cytosol membrane extracellular exosome plasma membrane cytoplasm dendrite cell projection Biological process phosphorylation MAPK cascade protein phosphorylation microtubule cytoskeleton organization establishment of cell polarity negative regulation of hippo signaling peptidyl-serine phosphorylation positive regulation of protein binding intracellular signal transduction peptidyl-serine autophosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4140 17169 Ensembl ENSG00000075413 ENSMUSG00000007411 UniProt P27448 Q03141 RefSeq (mRNA) NM_001128918 NM_001128919 NM_001128920 NM_001128921 NM_002376 NM_021516 NM_022801 NM_001370744 NM_001370745 RefSeq (protein) NP_001122390 NP_001122391 NP_001122392 NP_001122393 NP_002367 NP_067491 NP_073712 NP_001357673 NP_001357674 Location (UCSC) Chr 14: 103.39 – 103.5 Mb Chr 12: 111.54 – 111.62 Mb PubMed search [3] [4]
Wikidata
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Interactions

MARK3 has been shown to interact with Stratifin.^[7][8]

It has been linked to a form of genetic blindness, believed to be a genetic recessive disease that progressively destroys the eyes.^[9]