MARS (gene)

Methionyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the MARS gene.^[5][6]

MARS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DJV, 4BL7, 4BVX, 4BVY
Identifiers
Aliases	MARS1, METRS, MRS, MTRNS, SPG70, CMT2U, ILFS2, ILLD, methionyl-tRNA synthetase, methionyl-tRNA synthetase 1, MARS, TTD9
External IDs	OMIM: 156560; MGI: 1345633; HomoloGene: 90878; GeneCards: MARS1; OMA:MARS1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 57,475,445 bp[1] End 57,517,569 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 127,132,090 bp[2] End 127,147,655 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior pituitary right frontal lobe tendon of biceps brachii granulocyte epithelium of colon left lobe of thyroid gland right lobe of thyroid gland upper lobe of left lung body of pancreas Top expressed in lacrimal gland fossa primitive streak epiblast tail of embryo condyle seminal vesicula calvaria muscle of thigh abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity tRNA binding nucleotide binding ligase activity ATP binding RNA binding methionine-tRNA ligase activity Cellular component extracellular exosome membrane nucleolus cytoplasm aminoacyl-tRNA synthetase multienzyme complex cytosol nucleus Biological process protein biosynthesis tRNA aminoacylation for protein translation cellular response to starvation rRNA transcription cellular response to insulin stimulus cellular response to platelet-derived growth factor stimulus cellular response to epidermal growth factor stimulus positive regulation of transcription of nucleolar large rRNA by RNA polymerase I methionyl-tRNA aminoacylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4141 216443 Ensembl ENSG00000166986 ENSMUSG00000040354 UniProt P56192 Q68FL6 RefSeq (mRNA) NM_004990 NM_001003913 NM_001171582 RefSeq (protein) NP_004981 NP_001003913 NP_001165053 Location (UCSC) Chr 12: 57.48 – 57.52 Mb Chr 10: 127.13 – 127.15 Mb PubMed search [3] [4]
Wikidata
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Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene belongs to the class I family of tRNA synthetases.^[6]