MAST2

Microtubule-associated serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MAST2 gene.^[5] The protein encoded by this gene controls TRAF6 and NF-kappaB activity.^[6]

MAST2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KQF, 2KYL
Identifiers
Aliases	MAST2, MAST205, MTSSK, microtubule associated serine/threonine kinase 2
External IDs	OMIM: 612257; MGI: 894676; HomoloGene: 7428; GeneCards: MAST2; OMA:MAST2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.1 Start 45,786,987 bp[1] End 46,036,122 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 116,306,762 bp[2] End 116,464,183 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh apex of heart gastric mucosa glutes stromal cell of endometrium pancreatic ductal cell skeletal muscle tissue left ventricle left testis Top expressed in neural layer of retina muscle of thigh internal carotid artery right ventricle ankle joint cardiac muscle tissue of left ventricle external carotid artery ankle digastric muscle soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity phosphatase binding microtubule binding metal ion binding kinase activity protein serine/threonine kinase activity protein binding ATP binding magnesium ion binding Cellular component membrane microtubule cytoskeleton plasma membrane cytoskeleton cytoplasm Biological process intracellular signal transduction phosphorylation spermatid differentiation protein phosphorylation cytoskeleton organization peptidyl-serine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23139 17776 Ensembl ENSG00000086015 ENSMUSG00000003810 UniProt Q6P0Q8 Q60592 RefSeq (mRNA) NM_015112 NM_001319245 NM_001324320 NM_001324321 NM_001042743 NM_008641 NM_001369061 NM_001369062 RefSeq (protein) NP_001306174 NP_001311249 NP_001311250 NP_055927 NP_001036208 NP_032667 NP_001355990 NP_001355991 Location (UCSC) Chr 1: 45.79 – 46.04 Mb Chr 4: 116.31 – 116.46 Mb PubMed search [3] [4]
Wikidata
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Interactions

MAST2 has been shown to interact with PCLKC.^[7]