MNAT1

CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene.^[5]

MNAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G25
Identifiers
Aliases	MNAT1, CAP35, MAT1, RNF66, TFB3, CDK activating kinase assembly factor, MNAT1 component of CDK activating kinase
External IDs	OMIM: 602659; MGI: 106207; HomoloGene: 1821; GeneCards: MNAT1; OMA:MNAT1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.1 Start 60,734,742 bp[1] End 60,969,965 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 73,170,491 bp[2] End 73,320,762 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon muscle of thigh gastrocnemius muscle olfactory zone of nasal mucosa ventricular zone ganglionic eminence popliteal artery tibial arteries right uterine tube testicle Top expressed in tail of embryo epiblast primitive streak embryo embryo lens genital tubercle yolk sac ventricular zone mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP-dependent activity, acting on DNA protein N-terminus binding metal ion binding protein binding RNA polymerase II CTD heptapeptide repeat kinase activity cyclin-dependent protein serine/threonine kinase activator activity zinc ion binding Cellular component nucleoplasm nucleus cytosol transcription factor TFIIH holo complex cyclin-dependent protein kinase activating kinase holoenzyme complex Biological process termination of RNA polymerase I transcription regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription, DNA-templated adult heart development regulation of transcription by RNA polymerase II transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter negative regulation of apoptotic process 7-methylguanosine mRNA capping transcription by RNA polymerase II ventricular system development transcription, DNA-templated response to calcium ion cell cycle transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter cell population proliferation DNA repair positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle cell proliferation protein phosphorylation nucleotide-excision repair, preincision complex assembly positive regulation of cyclin-dependent protein serine/threonine kinase activity nucleotide-excision repair protein-containing complex assembly G1/S transition of mitotic cell cycle negative regulation of DNA helicase activity G2/M transition of mitotic cell cycle transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4331 17420 Ensembl ENSG00000020426 ENSMUSG00000021103 UniProt P51948 P51949 RefSeq (mRNA) NM_001177963 NM_002431 NM_008612 RefSeq (protein) NP_001171434 NP_002422 NP_032638 Location (UCSC) Chr 14: 60.73 – 60.97 Mb Chr 12: 73.17 – 73.32 Mb PubMed search [3] [4]
Wikidata
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Function

Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'ménage à trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM]^[6]

Interactions

MNAT1 has been shown to interact with:

• Cyclin H,^[7][8]
• Cyclin-dependent kinase 7,^[7][9]
• Estrogen receptor alpha,^[7]
• MCM7,^[10]
• MTA1,^[7]
• P53,^[11] and
• POU2F1.^[12]